Best Undergraduate Dissertations 2019. Since 2009 the Department of History at the University of Bristol has published the best of the annual dissertations produced by our final-year undergraduates. We do so in recognition of the excellent research undertaken by our students, which is a cornerstone of our degree programme. As a department, we are committed to the advancement of historical.
The Roles of Elevated Bcl-2 in Ovarian Cancer by Nicole Shree Anderson A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy Department of Pathology and Cell Biology College of Medicine University of South Florida Major Professor: Patricia A. Kruk, Ph.D. Santo V. Nicosia, M.D.
BCL-2 FAMILY FUNCTION IN ANTIESTROGEN-RESISTANT BREAST CANCER CELLS A Dissertation submitted to the Faculty of the Graduate School of Arts and Sciences of Georgetown University in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Tumor Biology By Anatasha Carissa Crawford, B.S. Washington, DC September 1, 2009.
We attached d-Ala residues to cross-linked helical peptides based on the pro-apoptotic protein Bad at their C-termini. The d-Ala attachment had little influence on the secondary structures and binding abilities against Bcl-XL. The d-Ala attached helical peptides were much more stable in cells than original o.
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BCL-X L, an anti-apoptotic BCL-2 family protein, plays a key role in cancer cell survival.However, the potential of BCL-X L as an anti-cancer target has been hampered by the on-target platelet toxicity because platelets depend on BCL-X L to maintain their viability. Here we report the development of a PROTAC BCL-X L degrader, XZ424, which has increased selectivity for BCL-X L-dependent MOLT-4.
Mechanism of caspase-3 activation and Mcl-1 inhibition in the regulation of apoptosis Open Access Ponder, Katelyn (Fall 2018). Intrinsic apoptosis is regulated by the Bcl-2 family of proteins. Upon an apoptotic stimuli proapoptotic proteins, Bak and Bax will form a multimer on the outer membrane of the mitochondria releasing cytochrome c and activate the caspase cascade. Understanding this.
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