Ankylosing spondylitis (AS) is a chronic inflammatory arthritis characterized by sacroiliitis, enthesitis (inflammation of the soft tissues attaching tendons, ligaments, and joint capsules to bone), and a marked propensity for sacroiliac joint (SJ) and spinal fusion. This arthritis is part of the spondyloarthritis (SpA) family of diseases, which have similar clinical, genetic, and immunologic.
In ankylosing spondylitis (AS) several parts of the lower spine become inflamed, including the bones in the spine (vertebrae) and spinal joints. Over time this can damage the spine and lead to the growth of new bone. In some cases this can cause parts of the spine to join up (fuse) and lose flexibility (ankylosis). It's not known exactly what causes AS, but in many cases there seems to be a.
The purpose of this study is to determine the benefit of taking 300mg of an investigational drug compared to the currently approved 150mg dose for patients with Ankylosing Spondylitis (AS). Qualified patients would come to our office for approximately 19 visits over a 52-week period. Patients will be given 16 doses of the investigational drug during the course of the study.
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Both ankylosing spondylitis (AS) and Crohn’s disease (CD) are chronic and potentially disabling interrelated conditions, which have been included under the group of spondyloarthropathies. The results of a large number of studies support the idea that an enteropathic pathogen, Klebsiella pneumoniae, is the most likely triggering factor involved in the initiation and development of these.
Anyone can get ankylosing spondylitis; however, certain factors may increase your risk for developing the disease, such as: Family history and genetics. If you have a family history of ankylosing spondylitis, you are more likely to develop the disease. Age. Most people develop symptoms of ankylosing spondylitis before age 45. Sex.
Ankylosing spondylitis (radiographic axial spondyloarthritis) is axial spondyloarthritis characterized by sacroiliitis on x-ray. Axial spondyloarthritis can also occur in the absence of x-ray changes and this is classified as non-radiographic axial spondyloarthritis (although changes may be visible on magnetic resonance imaging). Both conditions have similar presentations NICE, 2016; NICE.
Ankylosing spondylitis (AS) Arthritis of the spine, resembling rheumatoid arthritis, that may progress to bony ankyloses with lipping of vertical margins; the disease is more common in the male, often with the rheumatoid factor absent and the HLA antigen present.